Data edition of
Residue An evidence-graded reference for peptide science

Kisspeptin-10 clinical trials

Every study registered on ClinicalTrials.gov that lists Kisspeptin-10 as an intervention, as of the data edition — what is being tested, in whom, by whom, and how far it has got.

Registered studies
36
Active or recruiting
5
Completed
23
With posted results
7
Planned or actual enrollment
3,980participants, summed
Registered studies of Kisspeptin-10 by phase and status
PhaseStudiesBreakdown
Phase 1 11
7 completed, 1 active or recruiting, 3 stopped, 0 other
Phase 2 8
3 completed, 2 active or recruiting, 3 stopped, 0 other
Phase 3 3
3 completed, 0 active or recruiting, 0 stopped, 0 other
Not applicable 3
2 completed, 1 active or recruiting, 0 stopped, 0 other
Observational 11
8 completed, 1 active or recruiting, 0 stopped, 2 other
Figure 1. 36 studies on ClinicalTrials.gov match the registry search kisspeptin-10 OR kisspeptin. Multi-phase studies are counted at their highest phase. Open the full trial feed

Conditions studied

  1. Hypogonadotropic Hypogonadism10
  2. Reproductive Disorder4
  3. Kallmann Syndrome3
  4. Hypothalamic Amenorrhea2
  5. Delayed Puberty2
  6. GnRH Deficiency2
  7. Infertility2
  8. PCOS2
  9. Hyperprolactinemia2
  10. Polycystic Ovary Syndrome2
  11. Reproductive Age1
  12. PCOS (Polycystic Ovary Syndrome)1

Lead sponsors

  1. Stephanie B. Seminara, MD9
  2. Massachusetts General Hospital7
  3. Takeda2
  4. Vida Recoletas Sevilla2
  5. Imperial College London2
  6. Quaid-e-Azam University2
  7. Jagiellonian University1
  8. Istanbul University - Cerrahpasa1

The registry, study by study

Registration is not evidence of benefit; many registered studies never publish. Status and dates are as reported by sponsors to ClinicalTrials.gov.

Status
Phase

36 shown

Registered studies of Kisspeptin-10
StudyPhaseStatusStartnSponsor
NCT07224490Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease Phase 1 Recruiting Mar 2026 40 Stephanie B. Seminara, MD
NCT07224438Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea Phase 2 Recruiting Dec 2025 20 Stephanie B. Seminara, MD
NCT06793098Functional Proteins in Polycystic Ovary Syndrome Observational Recruiting Jan 2025 100 Jagiellonian University
NCT05896293Kisspeptin Administration Subcutaneously to Patients With IHH Phase 2 Recruiting Feb 2023 36 Stephanie B. Seminara, MD
NCT02081924Reproductive Hormones During Sustained Administration of Kisspeptin N/A Recruiting Apr 2014 76 Imperial College London
NCT06501729Kissing as a Protective Factor Against Acidic pH in Saliva N/A Completed Jul 2024 33 Universidad Catolica Santiago de Guayaquil
NCT06545994A Prospective Cohort Study on the Serum Kisspeptin Levels Throughout Pregnancy in PCOS Observational Unknown status Jun 2024 180 Fudan University
NCT05901467Recall by Genotype: Neuropeptide StimulationResults posted Phase 1 Terminated Oct 2023 16 Stephanie B. Seminara, MD
NCT05971849Dampening the Reproductive Axis With Continuous Kisspeptin Phase 1 Completed Oct 2023 8 Stephanie B. Seminara, MD
NCT05835089Evaluation of Some Puberty-related Hormones Among Children and Adolescents With Chronic Kidney Diseases Observational Unknown status May 2023 50 Sohag University
NCT05633966Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders Phase 1 Completed Dec 2022 13 Stephanie B. Seminara, MD
NCT05456854Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp Phase 1 Withdrawn Jun 2022 0 Massachusetts General Hospital
NCT04958109Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance TestResults posted Phase 1 Completed Oct 2021 16 Massachusetts General Hospital
NCT05971836The Molecular Basis of Inherited Reproductive Disorders Observational Completed Jan 2021 854 Stephanie B. Seminara, MD
NCT06775990Molecules Associated with Pediatric Obesity Observational Completed Jun 2020 60 Istanbul University - Cerrahpasa
NCT03877939Detection of Kisspeptins and miRNAs in Patients With Non-viable Pregnancy Observational Completed Sep 2019 433 Vida Recoletas Sevilla
NCT04532801Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance Phase 1 Withdrawn Sep 2019 0 Stephanie B. Seminara, MD
NCT04648969Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic HypogonadismResults posted Phase 2 Completed May 2019 18 Stephanie B. Seminara, MD
NCT03940495Serum Kisspeptin: a Predictive Marker of Miscarriage or Not? Observational Completed May 2019 182 ShangHai Ji Ai Genetics & IVF Institute
NCT04371991Kisspeptin Levels in Early Pregnancy Observational Completed Jan 2019 88 Semra Yuksel
NCT02956447Administration of Kisspeptin in Patients With HyperprolactinemiaResults posted Phase 2 Completed Nov 2017 36 Massachusetts General Hospital
NCT04012632Kisspeptin/GPR54 Pathway and Early Puberty Observational Completed Sep 2016 628 Shenzhen Center for Disease Control and Prevention
NCT03018314Serum Kisspeptin Levels in Infertile Women Observational Completed Jun 2016 90 Bakirkoy Dr. Sadi Konuk Research and Training Hospital
NCT02381288Effects of TAK-448 in Middle-aged and Older Men With Low TestosteroneResults posted Phase 2 Terminated Sep 2015 17 Takeda
NCT02369796A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic HypogonadismResults posted Phase 2 Terminated Feb 2015 15 Takeda
NCT03315325Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men Phase 3 Completed Aug 2014 15 Quaid-e-Azam University
NCT03286517Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys. Phase 3 Completed Jun 2014 30 Ghulam Nabi
NCT01952782Neuropeptides in Human Reproduction Phase 1 Completed Apr 2014 61 Massachusetts General Hospital
NCT02877992Tachykinin and Kisspeptin Expression in Human Granulosa and Cumulus Cells N/A Completed Jan 2014 236 Vida Recoletas Sevilla
NCT03771326KP-10 and Insulin Secretion in Men Phase 3 Completed Oct 2013 14 Quaid-e-Azam University
NCT01956851Association of Kisspeptin Levels With Insulin Secretion in Diabetes Mellitus Observational Completed Sep 2013 55 Ganga Care Hospital, Nagpur
NCT01438034Kisspeptin in the Evaluation of Delayed Puberty Phase 1 Completed Jun 2013 24 Massachusetts General Hospital
NCT01667406The Use of the Hormone Kisspeptin in 'in Vitro Fertilisation' (IVF) TreatmentResults posted Phase 2 Completed Jun 2012 175 Imperial College London
NCT01438073Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling Phase 1 Completed Sep 2011 96 Massachusetts General Hospital
NCT01132404Study in Men With Prostate Cancer to Assess the Safety, Pharmacokinetics and Testosterone-Lowering Efficacy of TAK-448 Phase 1/Phase 2 Terminated Nov 2010 9 Millennium Pharmaceuticals, Inc.
NCT00914823Kisspeptin Administration in the Adult Phase 1 Completed Jun 2009 256 Massachusetts General Hospital

Run this search on ClinicalTrials.gov → Query term: kisspeptin-10 OR kisspeptin