Kisspeptin-10 research
What PubMed holds on Kisspeptin-10, sorted by study design: the papers this site relies on, every clinical-trial publication PubMed tags, and the newest additions.
- PubMed records
- 317
- Trial publications
- 95 randomized
- Reviews
- 13
- Human-subject tagged
- 110
- Animal-only
- 172
- Clinical-trial publications 9
- Reviews 13
- Animal-only studies 172
- Other (in vitro, chemistry, commentary, unindexed) 123
Studies this site relies on
Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.
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Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men
Yeung AC, Phylactou M, Koysombat K, et al.
We demonstrate that chronic subcutaneous kisspeptin administration sustains gonadotropin and testosterone secretion in healthy men for 12 days. These data can inform development of chronic kisspeptin administration protocols for the treatment of reproductive disorders.
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Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism
George JT, Veldhuis JD, Tena-Sempere M, et al.
Kisspeptin-10 administration increased LH pulse frequency and LH secretion in hypotestosteronaemic men with T2DM in this proof-of-concept study, with associated increases in serum testosterone. These data suggest a potential novel therapeutic role for kisspeptin agonists in enhancing endogenous testosterone secretion in men with T2DM and …
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Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men
George JT, Veldhuis JD, Roseweir AK, et al.
Kisspeptin-10 boluses potently evoke LH secretion in men, and continuous infusion increases testosterone, LH pulse frequency, and pulse size. Kisspeptin analogues have therapeutic potential as regulators of LH and thus testosterone secretion.
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Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea
Millar RP, Sonigo C, Anderson RA, et al.
In this exploratory study, we demonstrated that administration of Kp-10 reactivated gonadotropin secretion in women with hPRL-HA and increased ovarian activity. Our data suggest that, as in rodents, GnRH deficiency in hPRL-HA is also mediated by an impairment of hypothalamic Kp secretion. Kp-10 or its analogues could have therapeutic …
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Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback
George JT, Anderson RA, Millar RP
STUDY FUNDING: Medical Research Council (UK). COMPETING INTERESTS: None.
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The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans
Jayasena CN, Nijher GM, Comninos AN, et al.
Kisspeptin-10 stimulates gonadotropin release in men as well as women during the preovulatory phase of menstrual cycle but fails to stimulate gonadotropin release in women during the follicular phase. The sexual dimorphism of the responsiveness of healthy men and women to kisspeptin-10 administration has important clinical implications …
Clinical-trial publications in PubMed
9 records carry PubMed’s clinical-trial publication type. Tagging is done by NLM indexers and occasionally includes secondary analyses.
Newest records
The most recent PubMed additions for this query at the data-edition date, regardless of design.
- Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche Clin Chim Acta · 2027 · Primary study
- Kisspeptin-10 alleviates OGD/R-induced H9c2 cardiomyocyte injury by triggering autophagy via regulating the YY1/TFEB axis Cytotechnology · 2026 · Primary study
- The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54 Mol Cell Endocrinol · 2026 · Primary study
- Kisspeptin-10 Alleviates Obesity-induced Testicular Oxidative Stress and Mitochondrial Dysfunction via Modulation of Mitophagy and Autophagy Signaling Reprod Sci · 2026 · Primary study
- Enzymatic Stability and Comparative Effects of Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation Metabolites · 2026 · Primary study
- Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism Cardiovasc Toxicol · 2026 · Primary study
- Structural basis for Kisspeptin-10 selectivity toward KISS1R: computational insights In Silico Pharmacol · 2026 · Primary study
- Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats Mol Neurobiol · 2026 · Primary study
- Exogenous Kisspeptin-10 inhibits ovarian cancer progression through targeting the SP1-hTERT-ZEB1 regulatory axis Cytotechnology · 2026 · Primary study