Data edition of
Residue An evidence-graded reference for peptide science

Sermorelin research

What PubMed holds on Sermorelin, sorted by study design: the papers this site relies on, every clinical-trial publication PubMed tags, and the newest additions.

PubMed records
366
Trial publications
6334 randomized
Reviews
10
Human-subject tagged
213
Animal-only
133
  • Clinical-trial publications 63
  • Reviews 10
  • Animal-only studies 133
  • Other (in vitro, chemistry, commentary, unindexed) 160
Figure 1. Composition of the Sermorelin literature by PubMed publication type and MeSH tags. Categories come from separate PubMed filters and can overlap; “animal-only” means tagged Animals and not Humans. Query: (sermorelin[tiab] OR "GHRH(1-29)"[tiab] OR "GRF(1-29)"[tiab]).
01836 1990: 36 records 1990 1991: 36 records 1992: 25 records 1993: 22 records 1994: 22 records 1995: 18 records 1995 1996: 19 records 1997: 14 records 1998: 11 records 1999: 12 records 2000: 6 records 2000 2001: 5 records 2002: 5 records 2003: 2 records 2004: 3 records 2005: 3 records 2005 2006: 3 records 2007: 2 records 2008: 2 records 2009: 3 records 2010: 2 records 2010 2011: 1 records 2012: 1 records 2013: 3 records 2014: 2 records 2015: 3 records 2015 2016: 3 records 2017: 2 records 2018: 4 records 2019: 3 records 2020: 2 records 2020 2021: 2 records 2022: 2 records 2023: 3 records 2024: 1 records 2025: 2 records 2025 2026: 7 records (year to date) 2026
Figure 2. PubMed records per publication year matching (sermorelin[tiab] OR "GHRH(1-29)"[tiab] OR "GRF(1-29)"[tiab]) — 366 in total; peak 36 in 1990. The 2026 bar is year-to-date (hatched). Volume of literature is not evidence of efficacy. Run this query on PubMed.

Studies this site relies on

Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.

  1. Randomized trial Acta Paediatr Suppl · 1993 PMID 8329830

    A comparative study of growth hormone (GH) and GH-releasing hormone(1-29)-NH2 for stimulation of growth in children with GH deficiency

    Chen RG, Shen YN, Yei J, et al.

    No serious side-effects were seen, but three patients receiving GHRH(1-29)-NH2 reported mild irritation at the injection site. These results from the continuous infusion of GHRH(1-29)-NH2 over 6 months suggest that this treatment, or the related use of a depot preparation, is unlikely to be as effective as GH for the promotion of growth …

  2. Randomized trial Acta Paediatr Suppl · 1993 PMID 8329825

    Pharmacokinetics of growth hormone-releasing hormone(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects after intravenous or intranasal administration

    Wilton P, Chardet Y, Danielson K, et al.

    The GH response after repeated intranasal administration of GHRH(1-29)-NH2 was sustained; there was no suppression of GH secretion during the night following a day when GHRH(1-29)-NH2 had been given three times intranasally. Based on these findings and the obvious convenience of intranasal administration compared with injections, it would …

  3. Primary study Clin Interv Aging · 2006 PMID 18046908

    Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?

    Walker RF

    No abstract is available in PubMed for this record.

  4. Primary study BioDrugs · 1999 PMID 18031173

    Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency

    Prakash A, Goa KL

    Sermorelin is a well tolerated analogue of GHRH which is suitable for use as a provocative test of growth hormone deficiency when given as a single intravenous 1 microg/kg bodyweight dose in conjunction with conventional tests. Limited data suggest that once daily subcutaneous sermorelin 30 microg/kg bodyweight is effective in promoting …

  5. Primary study Lancet · 1987 PMID 2879138

    Treatment of growth-hormone deficiency with growth-hormone-releasing hormone

    Ross RJ, Rodda C, Tsagarakis S, et al.

    GHRH (1-29) NH2 therapy is an alternative to conventional hGH in the treatment of some GH-deficient children. Ideal dose regimens need to be established.

Clinical-trial publications in PubMed

63 records carry PubMed’s clinical-trial publication type; the 40 most recent are listed. Tagging is done by NLM indexers and occasionally includes secondary analyses.

Clinical-trial publications on Sermorelin
YearTitleJournalDesign
2005Polyethylene glycol-conjugated growth hormone-releasing hormone is long acting and stimulates GH in healthy young and elderly subjectsEur J EndocrinolPhase 1 trial
2001Outcome of growth hormone therapy in children with growth hormone deficiency showing an inadequate response to growth hormone-releasing hormoneEndocrineClinical trial
2000The GH response to low-dose bolus growth hormone-releasing hormone (GHRH(1-29)NH2) is attenuated in patients with longstanding post-irradiation GH insufficiencyEur J EndocrinolRandomized trial
2000The negative GH auto-feedback in childhood: effects of rhGH and/or GHRH on the somatotroph response to GHRH or hexarelin, a peptidyl GH secretagogue, in childrenJ Endocrinol InvestClinical trial
1999The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostatin(1-14)(SS) in growth hormone (GH) pulse generation: studies in normal and post cranial irradiated individualsClin Endocrinol (Oxf)Randomized trial
1999The control on growth hormone release by free fatty acids is maintained in acromegalyJ Clin Endocrinol MetabRandomized trial
1998Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulationJ Clin Endocrinol MetabRandomized trial
1998Direct effects of corticotrophin-releasing hormone on stimulated growth hormone secretionClin Endocrinol (Oxf)Randomized trial
1997Interaction of the growth hormone releasing peptide hexarelin with somatostatinClin Endocrinol (Oxf)Clinical trial
1997Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and womenJ Clin Endocrinol MetabRandomized trial
1997Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and womenJ Clin Endocrinol MetabRandomized trial
1997Growth hormone release by the novel GH releasing peptide hexarelin in patients with homozygous beta-thalassemiaJ Pediatr Endocrinol MetabClinical trial
1997Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly menMetabolismClinical trial
1996Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response studyJ Clin Endocrinol MetabRandomized trial
1996The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivityClin Endocrinol (Oxf)Randomized trial
1996Long-term administration of acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid in obesityMetabolismClinical trial
1996Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study GroupJ Clin Endocrinol MetabClinical trial
1996Endogenous growth hormone (GH)-releasing hormone is required for GH responses to pharmacological stimuliJ Clin InvestRandomized trial
1996Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of actionDomest Anim EndocrinolRandomized trial
1996Plasma GH responses to human GHRH-antagonist in normal subjectsEur J EndocrinolClinical trial
1995Acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid levels in hyperthyroidismMetabolismClinical trial
1995The effect of hexarelin on growth hormone (GH) secretion in patients with GH deficiencyJ Clin Endocrinol MetabClinical trial
1995Comparison of the effects of growth hormone-releasing hormone and hexarelin, a novel growth hormone-releasing peptide-6 analog, on growth hormone secretion in humans with or without glucocorticoid excessJ EndocrinolRandomized trial
1995Role of galanin in the regulation of somatotrope and gonadotrope function in young ovulatory womenMetabolismRandomized trial
1995The effect of a continuous infusion of a somatostatin analogue (octreotide) for two years on growth hormone secretion and height prediction in tall childrenClin Endocrinol (Oxf)Clinical trial
1994Reciprocal relationship between the level of circulating cortisol and growth hormone secretion in response to growth hormone-releasing hormone in man: studies in patients with adrenal insufficiencyJ Clin Endocrinol MetabClinical trial
1994Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjectsJ Clin Endocrinol MetabRandomized trial
1994Priming with GHRH (1-29) NH2: an aid in differential diagnosis between hypothalamic and pituitary deficienciesJ Pediatr EndocrinolClinical trial
1994Long-term therapy with a single daily subcutaneous dose of growth hormone releasing hormone (1-29) in prepubertal growth hormone deficient children. Venezuelan Collaborative Study GroupJ Pediatr EndocrinolClinical trial
1994Low-dose growth hormone-releasing hormone tests: a dose-response studyEur J EndocrinolRandomized trial
1994Effect of pyridostigmine on the growth hormone response to growth hormone-releasing hormone in lean and obese type II Diabetic patientsMetabolismRandomized trial
1994Study on growth hormone and insulin secretion in myotonic dystrophyClin InvestigClinical trial
1994Physiological role of galanin in the regulation of anterior pituitary function in humansAm J PhysiolRandomized trial
1993Variability in the growth hormone response to growth hormone-releasing hormone alone or combined with pyridostigmine in type 1 diabetic patientsJ Endocrinol InvestClinical trial
1993A comparative study of growth hormone (GH) and GH-releasing hormone(1-29)-NH2 for stimulation of growth in children with GH deficiencyActa Paediatr SupplRandomized trial
1993Growth hormone (GH) profiles in response to continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 in children with GH deficiencyActa Paediatr SupplClinical trial
1993Intranasal administration of growth hormone-releasing hormone(1-29)-NH2 in children with growth hormone deficiency: effects on growth hormone secretion and growthActa Paediatr SupplClinical trial
1993Growth response to growth hormone-releasing hormone(1-29)-NH2 compared with growth hormoneActa Paediatr SupplRandomized trial
1993Pharmacokinetics of growth hormone-releasing hormone(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects after intravenous or intranasal administrationActa Paediatr SupplRandomized trial
1993Effect of galanin on the growth hormone (GH) response to GH-releasing hormone in patients with Cushing's diseaseEndocr ResRandomized trial

Newest records

The most recent PubMed additions for this query at the data-edition date, regardless of design.

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