Sermorelin dosage in clinical trials
What dose levels researchers actually tested, quoted from the trial registry and the published reports — so the numbers circulating online can be checked against their source.
Doses in published trials
| Trial | Population | Dose arms | Schedule | Ref. |
|---|---|---|---|---|
| Randomized vs growth hormone (1993) | Children with GH deficiency of hypothalamic origin; n=60, 20 per arm | 30 µg/kg/day; 60 µg/kg/day (comparator: GH 0.1 IU/kg/day) | Continuous SC infusion, 6 months | 1 |
| Pediatric treatment (1999 review) | Prepubertal children with idiopathic GH deficiency | 30 µg/kg | Once daily SC at bedtime; 12 months, limited data to 36 months | 2 |
| Diagnostic test (1999 review) | Children being tested for GH deficiency | 1 µg/kg | Single IV dose, with conventional tests | 2 |
| Pharmacokinetics (1993) | Healthy men aged 19–43; n=30 | 0.25–2 µg/kg IV (max GH response at 1–2 µg/kg); about 50 µg/kg intranasal | Single doses; intranasal also given three times in one day | 3 |
ClinicalTrials.gov lists 27 Sermorelin studies, but none of their registered arms names Sermorelin together with a dose, so this page quotes the published reports only.
References
Every source below was retrieved from its official API or page and cached on the data-edition date. Numbers match the margin notes.
- 1 PubMed Chen RG, Shen YN, Yei J, et al. A comparative study of growth hormone (GH) and GH-releasing hormone(1-29)-NH2 for stimulation of growth in children with GH deficiency. Acta Paediatr Suppl 1993. PMID 8329830; doi:10.1111/j.1651-2227.1993.tb12834.x.
- 2 PubMed Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs 1999. PMID 18031173; doi:10.2165/00063030-199912020-00007.
- 3 PubMed Wilton P, Chardet Y, Danielson K, et al. Pharmacokinetics of growth hormone-releasing hormone(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects after intravenous or intranasal administration. Acta Paediatr Suppl 1993. PMID 8329825; doi:10.1111/j.1651-2227.1993.tb12827.x.