MOTS-c research
What PubMed holds on MOTS-c, sorted by study design: the papers this site relies on, every clinical-trial publication PubMed tags, and the newest additions.
- PubMed records
- 264
- Trial publications
- 54 randomized
- Reviews
- 59
- Human-subject tagged
- 152
- Animal-only
- 54
- Clinical-trial publications 5
- Reviews 59
- Animal-only studies 54
- Other (in vitro, chemistry, commentary, unindexed) 146
Studies this site relies on
Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.
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MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Reynolds JC, Lai RW, Woodhead JST, et al.
In humans, exercise induces endogenous MOTS-c expression in skeletal muscle and in circulation. Our data indicate that aging is regulated by genes encoded in both of our co-evolved mitochondrial and nuclear genomes.
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MOTS-c reduces myostatin and muscle atrophy signaling
Kumagai H, Coelho AR, Wan J, et al.
These results suggest that through inhibition of myostatin, MOTS-c could be a potential therapy for insulin resistance-induced skeletal muscle atrophy as well as other muscle wasting phenotypes including sarcopenia.NEW & NOTEWORTHY MOTS-c, a mitochondrial-derived peptide reduces high-fat-diet-induced muscle atrophy signaling by reducing …
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Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals
Cataldo LR, Fernández-Verdejo R, Santos JL, et al.
Such dependence seems altered when obesity settles. The implications of plasma MOTS-c for human metabolic homeostasis deserve future examination.
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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C, Zeng J, Drew BG, et al.
MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity. These results suggest that mitochondria may actively regulate metabolic homeostasis at the cellular and organismal level via peptides encoded within their genome.
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MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation
Zheng Y, Wei Z, Wang T
Throughout this paper, we discussed the discovery and physiological function of mitochondrial-derived polypeptide MOTS-c, and the application of MOTS-c in the treatment of various diseases, such as aging, cardiovascular disease, insulin resistance, and inflammation. To provide additional ideas for future research and development, we …
Clinical-trial publications in PubMed
5 records carry PubMed’s clinical-trial publication type. Tagging is done by NLM indexers and occasionally includes secondary analyses.
| Year | Title | Journal | Design |
|---|---|---|---|
| 2025 | Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization | Med Sci Sports Exerc | Randomized trial |
| 2022 | Circulating levels of MOTS-c in patients with breast cancer treated with metformin | Aging (Albany NY) | Randomized trial |
| 2021 | Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans | J Appl Physiol (1985) | Randomized trial |
| 2021 | Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors | Sci Rep | Randomized trial |
| 2020 | β-Amyloid and mitochondrial-derived peptide-c are additive predictors of adverse outcome to high-on-treatment platelet reactivity in type 2 diabetics with revascularized coronary artery disease | J Thromb Thrombolysis | Clinical trial |
Newest records
The most recent PubMed additions for this query at the data-edition date, regardless of design.
- Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming Bioact Mater · 2027 · Primary study
- Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review Physiol Int · 2026 · Systematic review
- MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential Eur J Pharmacol · 2026 · Review
- Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility Tissue Cell · 2026 · Review
- MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation Autophagy · 2026 · Primary study
- Mitochondria-Endoplasmic Reticulum Crosstalk in Pancreatic β-Cell Stress: A Driver of Diabetes Cells · 2026 · Review
- MOTS-c mediates remote ischemic preconditioning-induced protection against lung ischemia-reperfusion injury via NRF2-dependent mitochondrial biogenesis Chin Med J (Engl) · 2026 · Primary study
- Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications J Bioenerg Biomembr · 2026 · Review
- Correction: Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction Sci Rep · 2026 · Primary study
- Emerging regulators of human physiology and disease; sORF-encoded microproteins Epigenomics · 2026 · Review