TB-500 research
What PubMed holds on TB-500, sorted by study design: the papers this site relies on, every clinical-trial publication PubMed tags, and the newest additions.
- PubMed records
- 1,157
- Trial publications
- 97 randomized
- Reviews
- 134
- Human-subject tagged
- 635
- Animal-only
- 399
- Clinical-trial publications 9
- Reviews 134
- Animal-only studies 399
- Other (in vitro, chemistry, commentary, unindexed) 615
Studies this site relies on
Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.
-
Thymosin beta-4 and venous ulcers: clinical remarks on a European prospective, randomized study on safety, tolerability, and enhancement on healing
Guarnera G, DE Rosa A, Camerini R
The study is ongoing and a total of 21 patients have been enrolled so far in the first treatment group at the lower dose. Patients' compliance and motivated and well-trained teams seem to be the most suitable parameters of a successfully conducted study.
-
Thymosin beta 4 ophthalmic solution for dry eye: a randomized, placebo-controlled, Phase II clinical trial conducted using the controlled adverse environment (CAE™) model
Sosne G, Ousler GW
This study confirms the efficacy of 0.1% Tβ4 as a topical treatment for relief of signs and symptoms of dry eye. Significant improvements in both signs and symptoms of dry eye were observed, and the treatment exhibited a large safety window, with no adverse events reported by any subjects enrolled in the study.
-
Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential
Esposito S, Deventer K, Goeman J, et al.
This work describes the detection and the identification of the N-terminal acetylated 17-23 fragment of human thymosin beta 4 (Ac-LKKTETQ) in TB-500 by means of high-performance liquid chromatography/high resolution mass spectrometry using an Orbitrap Exactive benchtop mass spectrometer. Ac-LKKTETQ was also synthesized by solid-phase …
-
Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry
Ho EN, Kwok WH, Lau MY, et al.
This method was successful in confirming the presence of N-acetylated LKKTETQ and its metabolites in equine urine and plasma collected from horses administered with a single dose of TB-500 (containing 10mg of N-acetylated LKKTETQ). To our knowledge, this is the first identification of TB-500 and its metabolites in post-administration …
-
Thymosin beta 4 and the eye: the journey from bench to bedside
Sosne G
Expert opinion: The electrifying possibility of Tβ4 as a revolutionary novel dry eye therapy is something that could have only been dreamed about just a few years ago. We believe that Tβ4 eyedrops will help many patients suffering from several ocular surface related disorders.
Clinical-trial publications in PubMed
9 records carry PubMed’s clinical-trial publication type. Tagging is done by NLM indexers and occasionally includes secondary analyses.
Newest records
The most recent PubMed additions for this query at the data-edition date, regardless of design.
- Identification of novel antimicrobial peptides and histone-derived cryptides in the hepatic transcriptome of Nile tilapia (Oreochromis niloticus) infected with Streptococcusagalactiae Fish Shellfish Immunol · 2026 · Primary study
- Sprayable bioadhesive microcarriers loaded with Tβ4-Engineered ADSC exosomes for diabetic wound healing Bioact Mater · 2026 · Primary study
- Understanding the effects of ciprofloxacin on corneal epithelial cells: a study using electric cell-substrate impedance sensing (ECIS) technology Exp Eye Res · 2026 · Primary study
- Case Report: Regenerative peptides for Inferior alveolar nerve injury: a narrative review with hypothesis-generating three clinical cases Front Oral Health · 2026 · Case report
- Exercise-specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring Equine Vet J · 2026 · Primary study
- Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management Curr Pain Headache Rep · 2026 · Review
- Recombinant human Thymosin β4 ameliorates experimental colitis and intestinal fibrosis through suppression of mineralocorticoid receptor signaling Mol Biomed · 2026 · Primary study
- Thymosin β4 Mitigates Acute Cerebral Infarction Via Inhibition of the TLR4/NF-κB Pathway and Suppression of Neuronal Pyroptosis Appl Biochem Biotechnol · 2026 · Primary study
- Thymosin β4 alleviates sepsis-associated acute kidney injury by suppressing MAPK signaling pathway Clin Sci (Lond) · 2026 · Primary study
- Peptide Supplements and Their Therapeutic Applications in Sports Medicine Am J Sports Med · 2026 · Primary study