Data edition of
Residue An evidence-graded reference for peptide science

Semax research

What PubMed holds on Semax, sorted by study design: the papers this site relies on, every clinical-trial publication PubMed tags, and the newest additions.

PubMed records
209
Trial publications
41 randomized
Reviews
11
Human-subject tagged
48
Animal-only
145
  • Clinical-trial publications 4
  • Reviews 11
  • Animal-only studies 145
  • Other (in vitro, chemistry, commentary, unindexed) 49
Figure 1. Composition of the Semax literature by PubMed publication type and MeSH tags. Categories come from separate PubMed filters and can overlap; “animal-only” means tagged Animals and not Humans. Query: (semax[tiab]).
0815 2000: 6 records 2000 2001: 10 records 2002: 5 records 2003: 11 records 2004: 10 records 2005: 8 records 2005 2006: 15 records 2007: 7 records 2008: 8 records 2009: 9 records 2010: 9 records 2010 2011: 5 records 2012: 7 records 2013: 11 records 2014: 7 records 2015: 7 records 2015 2016: 5 records 2017: 9 records 2018: 4 records 2019: 3 records 2020: 7 records 2020 2021: 9 records 2022: 4 records 2023: 3 records 2024: 4 records 2025: 8 records 2025 2026: 8 records (year to date) 2026
Figure 2. PubMed records per publication year matching (semax[tiab]) — 209 in total; peak 15 in 2006. The 2026 bar is year-to-date (hatched). Volume of literature is not evidence of efficacy. Run this query on PubMed.

Studies this site relies on

Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.

  1. Clinical trial Zh Nevrol Psikhiatr Im S S Korsakova · 2018 PMID 29798983

    [The efficacy of semax in the tretament of patients at different stages of ischemic stroke]

    Gusev EI, Martynov MY, Kostenko EV, et al.

    Early rehabilitation and administration of semax increase BDNF plasma level, speed functional recovery, and improve motor performance. Цель исследования. Изучить влияние семакса и времени начала реабилитационных мероприятий на динамику содержания нейротрофического фактора головного мозга (BDNF) в крови, степень восстановления двигательных …

  2. Clinical trial Zh Nevrol Psikhiatr Im S S Korsakova · 1997 PMID 11517472

    [Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)]

    Gusev EI, Skvortsova VI, Miasoedov NF, et al.

    It was established that including of Semax in combined intensive therapy of acute ischemic stroke had some influence on the rate of restoration of the damaged neurological functions in terms of increasing the regress of general cerebral and focal, especially motor disorders. The most effective daily doses were 12 mg for patients with …

  3. Primary study Mol Genet Genomics · 2017 PMID 28255762

    Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats

    Medvedeva EV, Dmitrieva VG, Limborska SA, et al.

    We suppose that neuroprotective mechanism of Semax is realized via the neuroimmune crosstalk, and the new properties of PGP were found under ischemia. Our results provided the basis for further proteomic investigations in the field of searching Semax neuroprotection mechanism.

  4. Primary study BMC Genomics · 2014 PMID 24661604

    The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis

    Medvedeva EV, Dmitrieva VG, Povarova OV, et al.

    Semax affects several biological processes involved in the function of various systems. The immune response is the process most markedly affected by the drug. Semax altered the expression of genes that modulate the amount and mobility of immune cells and enhanced the expression of genes that encode chemokines and immunoglobulins. In …

Clinical-trial publications in PubMed

4 records carry PubMed’s clinical-trial publication type. Tagging is done by NLM indexers and occasionally includes secondary analyses.

Clinical-trial publications on Semax
YearTitleJournalDesign
2018[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]Zh Nevrol Psikhiatr Im S S KorsakovaClinical trial
2007[The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax]Zh Nevrol Psikhiatr Im S S KorsakovaRandomized trial
2000[Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease]Vestn OftalmolClinical trial
1997[Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)]Zh Nevrol Psikhiatr Im S S KorsakovaClinical trial

Newest records

The most recent PubMed additions for this query at the data-edition date, regardless of design.

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