Selank research
What PubMed holds on Selank, sorted by study design: the papers this site relies on, every clinical-trial publication PubMed tags, and the newest additions.
- PubMed records
- 68
- Trial publications
- 32 randomized
- Reviews
- 3
- Human-subject tagged
- 15
- Animal-only
- 49
- Clinical-trial publications 3
- Reviews 3
- Animal-only studies 49
- Other (in vitro, chemistry, commentary, unindexed) 13
Studies this site relies on
Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.
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[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]
Zozulia AA, Neznamov GG, Siuniakov TS, et al.
The clinical-biological study revealed that patients with GAD and neurasthenia had the decreased level of tau(1/2) leu-enkephalin which was correlated with disease duration, severity of symptoms related to anxiety and asthenia and autonomic disorders. The increase of this parameter and stronger positive correlations with anxiety level …
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Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity
Vyunova TV, Andreeva L, Shevchenko K, et al.
Thus, we hypothesized and showed that one of Selank anti-anxiety molecular mechanisms can be associated with subtype selective concentration - dependent allosteric modulation of GABA receptors.
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Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission
Volkova A, Shadrina M, Kolomin T, et al.
Our results showed that Selank caused a number of alterations in the expression of genes involved in neurotransmission. The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.
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[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]
Uchakina ON, Uchakin PN, Miasoedov NF, et al.
The cytokine regulating effects revealed in the study suggest that selank can be used as a novel immunomodulator in patients with anxiety-asthenic disorders. Additionally, the adaptogenic properties of selank may be beneficial to its use in elderly people and people exposed to environmental stressors for the prevention of infectious …
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The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity
Zozulya AA, Kost NV, Yu Sokolov O, et al.
Selank was more potent than peptidase inhibitors bacitracin and puromycin in inhibiting enkephalinases. These results suggest that high efficiency of Selank in the therapy of anxiety and phobic disorders, including generalized anxiety, is due to its ability to inhibit enkephalin hydrolysis.
Clinical-trial publications in PubMed
3 records carry PubMed’s clinical-trial publication type. Tagging is done by NLM indexers and occasionally includes secondary analyses.
| Year | Title | Journal | Design |
|---|---|---|---|
| 2015 | [Optimization of the treatment of anxiety disorders with selank] | Zh Nevrol Psikhiatr Im S S Korsakova | Randomized trial |
| 2014 | [A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders] | Zh Nevrol Psikhiatr Im S S Korsakova | Clinical trial |
| 2008 | [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia] | Zh Nevrol Psikhiatr Im S S Korsakova | Randomized trial |
Newest records
The most recent PubMed additions for this query at the data-edition date, regardless of design.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions J Am Acad Orthop Surg Glob Res Rev · 2026 · Review
- Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats Bull Exp Biol Med · 2022 · Primary study
- Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank J Clin Pharmacol · 2021 · Primary study
- The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress Curr Rev Clin Exp Pharmacol · 2021 · Primary study
- Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank Bull Exp Biol Med · 2020 · Primary study
- The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind Drug Test Anal · 2020 · Primary study
- Functional Connectomic Approach to Studying Selank and Semax Effects Dokl Biol Sci · 2020 · Primary study
- Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats Bull Exp Biol Med · 2019 · Primary study
- Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress Bull Exp Biol Med · 2019 · Primary study
- State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment Bull Exp Biol Med · 2019 · Primary study