Data edition of
Residue An evidence-graded reference for peptide science

LL-37 clinical trials

Every study registered on ClinicalTrials.gov that lists LL-37 as an intervention, as of the data edition — what is being tested, in whom, by whom, and how far it has got.

Registered studies
20
Active or recruiting
2
Completed
12
With posted results
4
Planned or actual enrollment
1,192participants, summed
Registered studies of LL-37 by phase and status
PhaseStudiesBreakdown
Early phase 1 1
1 completed, 0 active or recruiting, 0 stopped, 0 other
Phase 1 1
0 completed, 0 active or recruiting, 1 stopped, 0 other
Phase 2 5
4 completed, 0 active or recruiting, 0 stopped, 1 other
Phase 3 1
0 completed, 0 active or recruiting, 1 stopped, 0 other
Not applicable 2
0 completed, 0 active or recruiting, 2 stopped, 0 other
Observational 10
7 completed, 2 active or recruiting, 0 stopped, 1 other
Figure 1. 20 studies on ClinicalTrials.gov match the registry search LL-37. Multi-phase studies are counted at their highest phase. Open the full trial feed

Conditions studied

  1. Rosacea2
  2. Periodontitis2
  3. Periodontal Diseases2
  4. Hypovitaminosis D1
  5. Tuberculosis1
  6. Diabetic Foot Ulcer1
  7. Oral Potentially Malignant Lesions1
  8. Peri Implantitis1
  9. Peri Implant Mucositis1
  10. Shigellosis1
  11. Passive Smoking1
  12. Oxidative Stress1

Lead sponsors

  1. University of California, San Diego2
  2. Emory University2
  3. Massachusetts General Hospital1
  4. Atlanta VA Medical Center1
  5. Fakultas Kedokteran Universitas Indonesia1
  6. Fayoum University1
  7. Recep Tayyip Erdogan University1
  8. International Centre for Diarrhoeal Disease Research, Bangladesh1

The registry, study by study

Registration is not evidence of benefit; many registered studies never publish. Status and dates are as reported by sponsors to ClinicalTrials.gov.

Status
Phase

20 shown

Registered studies of LL-37
StudyPhaseStatusStartnSponsor
NCT07280754Evaluation of 25(OH)D3 and LL-37 Levels in Periimplant Sulcus Fluid Observational Not yet recruiting Dec 2025 72 Recep Tayyip Erdogan University
NCT05054361Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in Children Observational Recruiting Jan 2022 180 Institut National de la Santé Et de la Recherche Médicale, France
NCT06219330Cathelicidin LL-37 Relation to Potentially Malignant Lesions Observational Completed Jul 2023 45 Fayoum University
NCT04946617Chlorhexidine and Essential Oil Mouthwashes on Human Beta-Defensin 2 (hbD2) and Kathelicidin (LL-37) Saliva Levels Observational Unknown status Jul 2021 120 Istanbul Medeniyet University
NCT04404335The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease. Observational Completed May 2021 60 Universidad Rey Juan Carlos
NCT06867250Peri-implant Vitamin D and Cathelicidin (LL-37) Levels Observational Completed Apr 2021 33 Altinbas University
NCT04861493Cathelicidin LL-37 Levels in the GCF and the Saliva of Smokers and Non-smokers With Stage III,IV Periodontitis Observational Completed Feb 2021 60 Cairo University
NCT04098562Efficacy of LL-37 Cream on Bacteria Colonization, Inflammation Response and Healing Rate of Diabetic Foot Ulcers Phase 2 Unknown status Oct 2019 40 Fakultas Kedokteran Universitas Indonesia
NCT03270709Effect of High-Dose Vitamin D3 in Smokers and Non-Smokers With and Without HIV Phase 1 Terminated Apr 2018 7 Emory University
NCT04292548Salivary TAS, TOS, LL-37 and Dental Status in Passive Smoking Children Observational Completed Nov 2016 180 Merve Erkmen Almaz
NCT03639376Passive Smoking and LL-37 in Children Observational Completed Nov 2016 180 Kırıkkale University
NCT02806414Evaluation of the Inhibitory Effects of Topical Ivermectin on Markers of Rosacea Specific Inflammation.Results posted Phase 1/Phase 2 Completed Jul 2016 25 University of California, San Diego
NCT02138591Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Major Surgical Procedures. Phase 3 Withdrawn Feb 2016 0 University of Missouri, Kansas City
NCT02225366Intratumoral Injections of LL37 for MelanomaResults posted Phase 1/Phase 2 Completed Jul 2015 4 M.D. Anderson Cancer Center
NCT01858051Vitamin D Status in Lower Extremity Joint Replacement Surgery Patients N/A Withdrawn Jan 2015 0 Massachusetts General Hospital
NCT03923218Effects of Smoking and Vitamin D3 on the Levels of Human Cathelicidin Peptide LL-37 Observational Completed Dec 2011 60 Gazi University
NCT01398280Effects of Aminocaproic Acid (ACA) on Rosacea-specific InflammationResults posted Early Ph 1 Completed Jul 2011 15 University of California, San Diego
NCT01372995Vitamin D in Ventilated ICU PatientsResults posted Phase 2 Completed Jul 2011 31 Emory University
NCT00788320Vitamin D in Active Tuberculosis (TB) Study N/A Withdrawn Oct 2008 0 Atlanta VA Medical Center
NCT00800930Therapeutic Induction of Endogenous Antibiotics Phase 2 Completed Jan 2005 80 International Centre for Diarrhoeal Disease Research, Bangladesh

Run this search on ClinicalTrials.gov → Query term: LL-37