KPV research

Studies this site relies on

Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.

1. Primary study Mol Ther · 2017 PMID 28143741

   Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

   Xiao B, Xu Z, Viennois E, et al.

   Oral administration of HA-KPV-NPs encapsulated in a hydrogel (chitosan/alginate) exhibited a much stronger capacity to prevent mucosa damage and downregulate TNF-α, thus they showed a much better therapeutic efficacy against UC in a mouse model, compared with a KPV-NP/hydrogel system. These results collectively demonstrate that our …

2. Primary study Gastroenterology · 2008 PMID 18061177

   PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation

   Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al.

   This study indicates tht KPV is transported into cells by PepT1 and might be a new therapeutic agent for IBD.

3. Primary study Inflamm Bowel Dis · 2008 PMID 18092346

   Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

   Kannengiesser K, Maaser C, Heidemann J, et al.

   The melanocortin-derived tripeptide KPV showed significant anti-inflammatory effects in 2 murine models of colitis. These effects seem to be at least partially independent of MC1R signaling. In conclusion, our data suggest KPV as an interesting therapeutic option for the treatment of IBD.

4. Primary study J Invest Dermatol · 2004 PMID 15102092

   alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells

   Elliott RJ, Szabo M, Wagner MJ, et al.

   Normal keratinocytes responded to all the above peptides but in addition responded to ACTH 1-17 (10(-13)-10(-7) M) in contrast to the HaCaT keratinocytes. Stable transfection of Chinese hamster ovary cells with the MC-1 receptor showed that alpha-MSH and the KPV peptides elevated intracellular calcium.

5. Primary study J Pharmacol Exp Ther · 2003 PMID 12750433

   Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides

   Getting SJ, Schiöth HB, Perretti M

   In conclusion, these data highlight that the C-terminal MSH peptide KPV exhibits an anti-inflammatory effect that is clearly different from that of the core MSH peptides. KPV is unlikely to mediate its effects through melanocortin receptors but is more likely to act through inhibition of IL-1beta functions.

Clinical-trial publications in PubMed

PubMed returns no publication tagged as a clinical trial for this query. That absence is itself a finding: claims about effects in people are not supported by trial reports indexed in PubMed.

Newest records

The most recent PubMed additions for this query at the data-edition date, regardless of design.

• Lysine-Proline-Valine attenuates oxidized low-density lipoprotein-induced foam cell formation and inflammatory responses in RAW264.7 macrophages Tissue Cell · 2026 · Primary study
• KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling Tissue Cell · 2026 · Primary study
• Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards Int J Pharm Compd · 2026 · Review
• A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review J Sports Med Phys Fitness · 2026 · Review
• Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells Cytotechnology · 2026 · Primary study
• NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development Cell Death Differ · 2026 · Primary study
• Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers Sci Adv · 2026 · Primary study
• Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease Drug Discov Today · 2025 · Review
• Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review Int J Med Sci · 2025 · Review
• Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway Tissue Cell · 2025 · Primary study