GHK-Cu research
What PubMed holds on GHK-Cu, sorted by study design: the papers this site relies on, every clinical-trial publication PubMed tags, and the newest additions.
- PubMed records
- 134
- Trial publications
- 11 randomized
- Reviews
- 14
- Human-subject tagged
- 47
- Animal-only
- 29
- Clinical-trial publications 1
- Reviews 14
- Animal-only studies 29
- Other (in vitro, chemistry, commentary, unindexed) 90
Studies this site relies on
Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.
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Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin
Miller TR, Wagner JD, Baack BR, et al.
Copper tripeptide complex (GHK-Cu) skin care products placed on CO(2) laser-resurfaced skin offered no significant reduction or resolution of posttreatment erythema. Objective evaluation found no significant improvement in wrinkles or overall skin quality. However, patient satisfaction was significantly higher for those who used GHK-Cu …
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Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
Pickart L, Margolina A
GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, anti-pain …
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GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
Pickart L, Vasquez-Soltero JM, Margolina A
It is capable of up- and downregulating at least 4,000 human genes, essentially resetting DNA to a healthier state. The present review revisits GHK's role in skin regeneration in the light of recent discoveries.
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The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health
Pickart L, Vasquez-Soltero JM, Margolina A
Recent studies revealed its ability to up- and downregulate a large number of human genes including those that are critical for neuronal development and maintenance. We propose GHK tripeptide as a possible therapeutic agent against age-associated neurodegeneration and cognitive decline.
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The human tri-peptide GHK and tissue remodeling
Pickart L
GHK-Cu also improves hair transplant success, protects hepatic tissue from tetrachloromethane poisoning, blocks stomach ulcer development, and heals intestinal ulcers and bone tissue. These results are beginning to define the complex biochemical processes that regulate tissue remodeling.
Clinical-trial publications in PubMed
1 records carry PubMed’s clinical-trial publication type. Tagging is done by NLM indexers and occasionally includes secondary analyses.
| Year | Title | Journal | Design |
|---|---|---|---|
| 2006 | Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin | Arch Facial Plast Surg | Randomized trial |
Newest records
The most recent PubMed additions for this query at the data-edition date, regardless of design.
- Hierarchical regulation and mechanism of "open-hollow-fibrous network" structures: Osteogenic-angiogenic coupling responses of poly(γ-benzyl-L-glutamate) microspheres Biomater Adv · 2026 · Primary study
- Characterization of copper tripeptide-loaded lipid carriers and their stability in complex cosmetic matrices J Chromatogr A · 2026 · Primary study
- A tea exosome-integrated self‑oxygenating cascade chitosan/oxidized alginate hydrogel for remodeling the hyperglycemic and hypoxic microenvironment in diabetic wound healing Carbohydr Polym · 2026 · Primary study
- Water-Soluble, Enzyme-Degradable, and Hydrolyzable STAR Particles for Enhanced Drug Delivery to Skin Adv Healthc Mater · 2026 · Primary study
- Microenvironment-responsive injectable dynamic hydrogel for sequential antioxidant and tissue regeneration therapy of radiation-induced skin injury Bioact Mater · 2026 · Primary study
- GHK-Cu as a Bioactive Metallopeptide and Drug-Delivery Cargo: Coordination Chemistry, Formulation Science, Therapeutic Evidence, and a Translational Roadmap Pharmaceutics · 2026 · Review
- Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management Curr Pain Headache Rep · 2026 · Review
- The Regenerative Potential of GHK-Cu in Aesthetic Medicine Aesthet Surg J · 2026 · Primary study
- Peptide Supplements and Their Therapeutic Applications in Sports Medicine Am J Sports Med · 2026 · Primary study
- Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu Skin Res Technol · 2026 · Primary study