Data edition of
Residue An evidence-graded reference for peptide science

DSIP research

What PubMed holds on DSIP, sorted by study design: the papers this site relies on, every clinical-trial publication PubMed tags, and the newest additions.

PubMed records
463
Trial publications
186 randomized
Reviews
24
Human-subject tagged
111
Animal-only
322
  • Clinical-trial publications 18
  • Reviews 24
  • Animal-only studies 322
  • Other (in vitro, chemistry, commentary, unindexed) 99
Figure 1. Composition of the DSIP literature by PubMed publication type and MeSH tags. Categories come from separate PubMed filters and can overlap; “animal-only” means tagged Animals and not Humans. Query: ("delta sleep-inducing peptide"[tiab] OR DSIP[tiab] OR emideltide[tiab]).
01326 1990: 21 records 1990 1991: 20 records 1992: 26 records 1993: 13 records 1994: 17 records 1995: 21 records 1995 1996: 10 records 1997: 9 records 1998: 15 records 1999: 8 records 2000: 4 records 2000 2001: 11 records 2002: 7 records 2003: 15 records 2004: 10 records 2005: 2 records 2005 2006: 7 records 2007: 4 records 2008: 6 records 2009: 5 records 2010: 2 records 2010 2011: 4 records 2012: 5 records 2013: 5 records 2014: 9 records 2015: 3 records 2015 2016: 2 records 2017: 2 records 2018: 1 records 2019: 0 records 2020: 2 records 2020 2021: 3 records 2022: 0 records 2023: 1 records 2024: 2 records 2025: 1 records 2025 2026: 1 records (year to date) 2026
Figure 2. PubMed records per publication year matching ("delta sleep-inducing peptide"[tiab] OR DSIP[tiab] OR emideltide[tiab]) — 463 in total; peak 26 in 1992. The 2026 bar is year-to-date (hatched). Volume of literature is not evidence of efficacy. Run this query on PubMed.

Studies this site relies on

Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.

  1. Randomized trial Neuropsychobiology · 1992 PMID 1299794

    Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study

    Bes F, Hofman W, Schuur J, et al.

    Data analysis suggested, however, that the statistically significant effects were weak and in part could be due to an incidental change in the placebo group. As none of the other measures, including subjective sleep quality, showed any change, it was concluded that short-term treatment of chronic insomnia with DSIP is not likely to be of …

  2. Clinical trial Eur Neurol · 1987 PMID 3622582

    Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia

    Schneider-Helmert D

    Alertness and performance at daytime increased significantly. The study demonstrates the efficacy of DSIP for the treatment of impaired sleep and daytime functions as well.

  3. Clinical trial Eur Neurol · 1984 PMID 6391925

    DSIP in insomnia

    Schneider-Helmert D

    A case of insomnia in organic brain disease responded well to higher doses. The results are discussed as to the mode of action of DSIP and its possible therapeutic use in insomnia.

  4. Clinical trial Neuropsychobiology · 1983 PMID 6689058

    Effects of DSIP in man. Multifunctional psychophysiological properties besides induction of natural sleep

    Schneider-Helmert D, Schoenenberger GA

    The various actions of DSIP might be conceptualized neurophysiologically on the level of 'programming' behavior by means of changing 'local vigilances'. Whereas the somnogenic actions of DSIP appear promising for treating insomnia, other therapeutic perspectives in the field of psychiatry have to be explored.

  5. Review J Neurochem · 2006 PMID 16539679

    Delta sleep-inducing peptide (DSIP): a still unresolved riddle

    Kovalzon VM, Strekalova TV

    This assumption is based on: (i) a highly specific distribution of DSIP-like immunoreactivity in the neurosecretory hypothalamic nuclei of various vertebrate species that are not particularly relevant for sleep regulation, as revealed by the histochemical studies of the Geneva group (Charnay et al.); (ii) a large spectrum of DSIP …

Clinical-trial publications in PubMed

18 records carry PubMed’s clinical-trial publication type. Tagging is done by NLM indexers and occasionally includes secondary analyses.

Clinical-trial publications on DSIP
YearTitleJournalDesign
2016An RCT study on the feasibility of anterior transpedicular screw fixation in the cervicothoracic junctionEur Spine JRandomized trial
2014[Using deltalicin for the treatment of patients with diabetic retinopathy]Eksp Klin FarmakolClinical trial
2009Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesiaEur J AnaesthesiolRandomized trial
1998Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trialJ Clin PsychopharmacolClinical trial
1995Delta-sleep-inducing peptide does not affect CRH and meal-induced ACTH and cortisol secretionPsychoneuroendocrinologyClinical trial
1994Plasma concentration of nine hormones and neurotransmitters during usual activities or constant bed rest for 34 HChronobiol IntClinical trial
1994Different effects of delta-sleep-inducing peptide on arginine-vasopressin and ACTH secretion in normal menHorm ResRandomized trial
1993Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal womenPsychoneuroendocrinologyClinical trial
1992Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind studyNeuropsychobiologyRandomized trial
1989Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in manPsychoneuroendocrinologyRandomized trial
1987Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomniaEur NeurolClinical trial
1987Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacsInt J Clin Pharmacol ResClinical trial
1984A clinical trial with DSIPEur NeurolClinical trial
1984DSIP in insomniaEur NeurolClinical trial
1983Effects of DSIP in man. Multifunctional psychophysiological properties besides induction of natural sleepNeuropsychobiologyClinical trial
1981Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behaviorInt J Clin Pharmacol Ther ToxicolClinical trial
1981Synthetic delta-sleep-inducing peptide improves sleep in insomniacsLancetRandomized trial
1981The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleepExperientiaClinical trial

Newest records

The most recent PubMed additions for this query at the data-edition date, regardless of design.

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