Data edition of
Residue An evidence-graded reference for peptide science

BPC-157 research

What PubMed holds on BPC-157, sorted by study design: the papers this site relies on, every clinical-trial publication PubMed tags, and the newest additions.

PubMed records
225
Trial publications
00 randomized
Reviews
50
Human-subject tagged
54
Animal-only
105
  • Clinical-trial publications 0
  • Reviews 50
  • Animal-only studies 105
  • Other (in vitro, chemistry, commentary, unindexed) 70
Figure 1. Composition of the BPC-157 literature by PubMed publication type and MeSH tags. Categories come from separate PubMed filters and can overlap; “animal-only” means tagged Animals and not Humans. Query: ("BPC 157"[tiab] OR "BPC-157"[tiab] OR "PL 14736"[tiab]).
01530 2000: 2 records 2000 2001: 9 records 2002: 1 records 2003: 3 records 2004: 3 records 2005: 4 records 2005 2006: 6 records 2007: 3 records 2008: 5 records 2009: 10 records 2010: 7 records 2010 2011: 6 records 2012: 3 records 2013: 5 records 2014: 4 records 2015: 6 records 2015 2016: 9 records 2017: 11 records 2018: 8 records 2019: 5 records 2020: 12 records 2020 2021: 19 records 2022: 13 records 2023: 10 records 2024: 7 records 2025: 16 records 2025 2026: 30 records (year to date) 2026
Figure 2. PubMed records per publication year matching ("BPC 157"[tiab] OR "BPC-157"[tiab] OR "PL 14736"[tiab]) — 225 in total; peak 30 in 2026. The 2026 bar is year-to-date (hatched). Volume of literature is not evidence of efficacy. Run this query on PubMed.

Studies this site relies on

Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.

  1. Primary study Altern Ther Health Med · 2024 PMID 39325560

    Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study

    Lee E, Walker C, Ayadi B

    This is the first report of intravesical BPC-157 (10 mg) injection to help patients with moderate to severe interstitial cystitis who did not respond to pentosan polysulfate treatment.

  2. Primary study Altern Ther Health Med · 2021 PMID 34324435

    Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain

    Lee E, Padgett B

    This small study suggests that intra-articular injection of BPC-157 helps with multiple types of knee pain.

  3. Review HSS J · 2025 PMID 40756949

    Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

    Vasireddi N, Hahamyan H, Salata MJ, et al.

    Animal studies showed no harmful effects, but there is no clinical safety data in humans. Overall, BPC-157 could help heal musculoskeletal injuries, but there are potential risks due to unregulated production and lack of clinical safety data.

  4. Review Curr Rev Musculoskelet Med · 2025 PMID 40789979

    Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing

    McGuire FP, Martinez R, Lenz A, et al.

    Until well-designed clinical trials are conducted, BPC-157 should be considered investigational, and its use approached with caution. This review highlights that given the robust preclinical evidence and high public interest, there is a critical need for well-designed human trials to assess the safety, efficacy, and clinical utility of …

  5. Review Front Pharmacol · 2021 PMID 34267654

    Stable Gastric Pentadecapeptide BPC 157 and Wound Healing

    Seiwerth S, Milavic M, Vukojevic J, et al.

    Future Directions: BPC 157 rapidly increases various genes expression in rat excision skin wound. This would define the healing in the other tissues, that is, gastrointestinal tract, tendon, ligament, muscle, bone, nerve, spinal cord, cornea (maintained transparency), and blood vessels, seen with BPC 157 therapy.

  6. Review Cell Tissue Res · 2019 PMID 30915550

    Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing

    Gwyer D, Wragg NM, Wilson SL

    Moreover, skeletal muscle injury models have suggested a beneficial effect not only for disturbances that occur as a result of direct trauma but also for systemic insults including hyperkalamia and hypermagnesia. Promisingly, there are few studies reporting any adverse reactions to the administration of BPC 157, although there is still a …

Clinical-trial publications in PubMed

PubMed returns no publication tagged as a clinical trial for this query. That absence is itself a finding: claims about effects in people are not supported by trial reports indexed in PubMed.

Newest records

The most recent PubMed additions for this query at the data-edition date, regardless of design.

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