AOD-9604 research

Studies this site relies on

Ordered by strength of design. Conclusions are quoted verbatim from each abstract as indexed by PubMed; read the full paper before relying on any of them.

1. Primary study Drug Test Anal · 2013 PMID 24124033

   AOD-9604 does not influence the WADA hGH isoform immunoassay

   Orlovius AK, Thomas A, Schänzer W, et al.

   No abstract is available in PubMed for this record.

2. Primary study Endocrinology · 2001 PMID 11713213

   The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice

   Heffernan M, Summers RJ, Thorburn A, et al.

   However, in an acute experiment, AOD9604 was capable of increasing energy expenditure and fat oxidation in the beta(3)-AR knock-out mice. In conclusion, this study demonstrates that the lipolytic actions of both hGH and AOD9604 are not mediated directly through the beta(3)-AR although both compounds increase beta(3)-AR expression, which …

3. Primary study Int J Obes Relat Metab Disord · 2001 PMID 11673763

   Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment

   Heffernan MA, Thorburn AW, Fam B, et al.

   Both hGH and its C-terminal fragment reduce body weight gain, increase fat oxidation, and stimulate lipolysis in obese mice, yet AOD9604 does not interact with the hGH receptor. Thus, the concept of hGH behaving as a pro-hormone is further confirmed. This data shows that fragments of hGH can act in a manner novel to traditional …

4. Primary study Horm Res · 2000 PMID 11146367

   Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone

   Ng FM, Sun J, Sharma L, et al.

   In contrast to chronic treatment with intact hGH, chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity of the animals, as demonstrated with euglycemic clamp techniques. The results in the present study suggest that the analogue of the hGH lipolytic domain may have the potential to be developed into an orally …

5. Review Curr Opin Investig Drugs · 2004 PMID 15134286

   AOD-9604 Metabolic

   Wilding J

   Metabolic is developing AOD-9604 for the potential treatment of obesity. By February 2002, phase IIa trials were underway.

Clinical-trial publications in PubMed

PubMed returns no publication tagged as a clinical trial for this query. That absence is itself a finding: claims about effects in people are not supported by trial reports indexed in PubMed.

Newest records

The most recent PubMed additions for this query at the data-edition date, regardless of design.

• Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance Sports Med · 2026 · Review
• Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices Analyst · 2026 · Primary study
• The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration Front Endocrinol (Lausanne) · 2026 · Review
• Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions J Am Acad Orthop Surg Glob Res Rev · 2026 · Review
• Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry J Sep Sci · 2016 · Primary study
• Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model Ann Clin Lab Sci · 2015 · Primary study
• Detection and in vitro metabolism of AOD9604 Drug Test Anal · 2015 · Primary study
• Detecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions Expert Rev Proteomics · 2014 · Primary study
• Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls J Pharm Biomed Anal · 2014 · Review
• Identification and characterization of peptide drugs in unknown pharmaceutical preparations seized by the Belgian authorities: case report on AOD9604 Drug Test Anal · 2014 · Primary study